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Long-acting GIPRA inhibits feeding and lowers body weight in mice with diet-induced obesity

The hormone glucose-dependent insulinotropic polypeptide (GIP) is considered obesogenic. In contrast, GIP receptor agonists (GIPRAs) have shown reduced feeding and body weight in an obese mouse model. Therefore, the precise effects exerted by GIP and GIPRAs remain elusive.
Japan General Toshihiko Yada Wanxin Han Daisuke Yabe Yutaka Seino Emily Henderson

Correcting abnormalities in solid tumor's blood vessels can improve efficacy of CAR-T cell therapy

A type of immune therapy called chimeric antigen receptor (CAR)-T cell therapy has revolutionized the treatment of multiple types of blood cancers but has shown limited efficacy against glioblastoma-;the deadliest type of primary brain cancer-;and other solid tumors.
United States Jun Ren Meenal Datta Sylvie Roberge Dai Fukumura Mark Duquette

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No increased risk of neuropsychiatric events in children born to mothers using leukotriene-receptor antagonists in pregnancy

A new study examined the associations between leukotriene-receptor antagonists (LTRAs) use in pregnancy and neuropsychiatric events (NEs) risk in the offspring.
United States International Classification Of Diseases Drug Administration National Health Insurance Research Database Leukotriene Receptor Antagonists During Pregnancy Neuropsychiatric Events

Study paves the way to new sex-specific anti-obesity drugs

Sex differences exist in the regulation of energy homeostasis, the organism's mechanism to keep a stable body weight. Current studies indicate for instance that female mammals, including humans, are better protected against metabolic diseases during reproductive age.
Cristina Garc Emily Henderson Ludwig Maximilians University Diabetes Research World Health Organization German Center

Tumors' response to hormone therapy may be a biomarker for personalization of breast radiotherapy

How estrogen receptor-positive (ER+) breast cancer responds to hormone therapy may hold keys to understanding how it will respond to radiation therapy, and an experimental drug that increases the effectiveness of hormone therapy also overcomes radiation resistance in breast cancer, a study by UT Southwestern Medical Center researchers shows.
D Nathan Kim Guemhee Baek Rams Mani Kamal Pandey Asals Rahimi Emily Henderson

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