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Two simple biomarkers could differentiate which young women with ER+ breast cancer need chemotherapy

New research from Yale Cancer Center identified that two simple biomarkers, immune cells and estrogen receptor levels, could differentiate which young women with ER+ breast cancer need chemotherapy to improve their survival, and which only need a monthly injection to suppress ovarian function.
Baden Wüberg Michal Marczyk Mariya Rozenblit Tao Qing Naing Lin Shan Kim Blenman

Study points to a pathogenic role for compromised anti-SARS-CoV-2 responses in cerebrospinal fluid

Researchers used a high throughput systems serology method to compare serum and CSF samples from SARS-CoV-2 infected individuals with and without long COVID symptoms to determine changes in the SARS-CoV-2 humoral immune responses.
Hong Kong Hcov Hong Kong University Lab Diagnostics Automation Lab Diagnostics Automation Industry Image Credit Automation Industry Focus

First placebo-controlled long-term trial of anifrolumab shows positive results in patients with lupus

Type I interferon (IFN) is a powerful immune activator that is present at high levels in the majority of patients with lupus, an autoimmune disease. In Arthritis & Rheumatology, researchers report positive results from the first placebo-controlled long-term trial of anifrolumab-;a human monoclonal antibody that targets the type I IFN receptor-;in patients with lupus.
Hussein Al Mossawi Emily Henderson Corresponding Author Autoimmune Disease Lupus Erythematosus Monoclonal Antibody

SARS-CoV-2 spike subunit conformation determines plasma-neutralizing activity triggered by COVID-19 vaccines and natural infection

In a new study, researchers evaluated the effect of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike (S) glycoprotein conformation on S-directed neutralizing antibodies (nAbs).
Aimee Molineux Neha Mathurnov Neha Mathur Michal Bednarek Shutterstock Lab Diagnostics Automation Lab Diagnostics Automation Industry

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Structure-directed mutagenesis produces thermostable SARS-CoV-2 spike protein trimers with potential vaccine booster applications

Researchers investigated the change in the stability, antigenicity, and protein expression of the SARS-CoV-2 spike protein trimer using structure-directed mutagenesis to alter a cavity in the core of the spike protein.
Lab Diagnostics Automation Lab Diagnostics Automation Industry Automation Industry Focus Image Credit Coronavirus Disease Covid 19 Ars Cov 2

Study suggests the rapid expansion of naïve T cells can provide a fast and effective immune response to SARS-CoV-2 and other viral infections

Researchers investigated the early T cell responses during SARS-CoV-2 infections to understand the mechanisms of rapid clonal expansion that characterize the T cell responses to acute infections and vaccinations.
United Kingdom City Of Kateryna Kon Shutterstock Coronavirus Disease Covid 19 Immune Response Ars Cov 2

New CRISPR approach is a leap forward in developing personalized treatment for cancer

For the first time, scientists have used CRISPR technology to insert genes that allow immune cells to focus their attack on cancer cells, potentially leaving normal cells unharmed and increasing the effectiveness of immunotherapy.
Antoni Ribas James Heath David Baltimore Emily Henderson Institute For Systems Biology In Seattle Society For Immunotherapy Of Cancer

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