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European Commission Approves Elacestrant for Pretreated, ESR1+, ER+/HER2– Breast Cancer

The European Commission has approved elacestrant for the treatment of postmenopausal women and men with estrogen receptor–positive, HER2-negative, locally advanced, or metastatic breast cancer with an activating ESR1 mutation who have disease progression following at least 1 line of endocrine therapy including a CDK4/6 inhibitor.
San Antonio United States Elcin Barker Ergun Giuseppe Curigliano European Institute Of Oncology Division Of Early Drug Development

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FDA Approval Insights: Elacestrant in ER+/HER2– ESR1-mutated Advanced or Metastatic Breast Cancer

Dr Bidard discusses the FDA approval of elacestrant in patients with estrogen receptor–positive, HER2-negative, ESR1-mutated advanced or metastatic breast cancer, key efficacy and safety data from the EMERALD trial, and the importance of testing for ESR1 mutations in patients with ER-positive, HER2-negative disease.
France General Francois Clement Bidard Ashling Wahner Institut Curie Breast Cancer Research Stemline Therapeutics

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