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'Good cholesterol' may protect liver – Washington University School of Medicine in St. Louis

Brad W. Warner A new study from Washington University School of Medicine in St. Louis shows that a type of good cholesterol called HDL3, when produced in the intestine, protects the liver from inflammation and injury. First author Yong-Hyun Han, PhD, (left) and co-author and Washington University surgical resident Emily Onufer, MD, work in the surgical suite where the mouse surgeries were conducted as part of this study. Han did this work while a postdoctoral researcher in the lab of senior author Gwendalyn Randolph, PhD. The body’s so-called good cholesterol may be even better than we realize. New research from Washington University School of Medicine in St. Louis suggests that one type of high-density lipoprotein (HDL) has a previously unknown role in protecting the liver from injury. This HDL protects the liver by blocking inflammatory signals produced by common gut bacteria.

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