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Study sheds light on why some patients respond better than others to immunotherapy

Immunotherapy, a biotherapy that boosts the ability of the immune system to recognize and attack mutant tumor cells, has transformed the treatment landscape for patients battling cancer, which emerges from the progressive accumulation of DNA mutations.
United States Bryan Chow Alessandro Santin Emily Henderson American Association For Cancer Research Systems Biology Institute

Research reveals a differential clinical response to pembrolizumab in uterine cancer patients

New research from Yale Cancer Center reveals for the first time ever a differential clinical response to pembrolizumab in Lynch-like (mutated) vs methylated microsatellite instability-high (MSI-H) uterine cancer patients, increasing our understanding about the proportion of patients that derive benefit from immune checkpoint blockade.
Elena Bonazzoli Akiko Iwasaki Bryan Chow Stefania Bellone Alessandro Santin Tai Michaels

Why immunotherapy works well for some cancer patients, but not others

Immunotherapy, a biotherapy that boosts the ability of the immune system to recognize and attack mutant tumor cells, has transformed the treatment landscape for patients battling cancer, which emerges from the progressive accumulation of DNA mutations. However, many patients do not respond to immunotherapy.
United States Bryan Chow Alessandro Santin American Association For Cancer Research Systems Biology Institute Yale School Of Medicine

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