You may have been wondering which European country is currently at the forefront of the technological revolution, setting a remarkable example for the rest of the world. Estonia is an incredible example. Estonia has made a name for itself in the tech world, but what about its technological prowess? Let's take a tour around Estonia's
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The substantial investments in human genetics and genomics made over the past three decades were anticipated to result in many innovative therapies. Here we investigate the extent to which these expectations have been met, excluding cancer treatments. In our search, we identified 40 germline genetic observations that led directly to new targets and subsequently to novel approved therapies for 36 rare and 4 common conditions. The median time between genetic target discovery and drug approval was 25 years. Most of the genetically driven therapies for rare diseases compensate for disease-causing loss-of-function mutations. The therapies approved for common conditions are all inhibitors designed to pharmacologically mimic the natural, disease-protective effects of rare loss-of-function variants. Large biobank-based genetic studies have the power to identify and validate a large number of new drug targets. Genetics can also assist in the clinical development phase of drugs—for example
The Estonian site of international business accelerator Creative Destruction Lab (CDL) was officially launched at the University of Tartu (TÜ) during sTARTUp Day on Friday. Nearly 50 startups have already applied to join the accelerator, which aims to bring together research-intensive European startups focused on digital governance, health data and cybersecurity.