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Plasma biomarker screening could improve accuracy, health equity in Alzheimer s disease diagnosis
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Florida increases state funding for Alzheimer s disease to $51 million - News
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IMAGE: The enhanced physical activity group underwent 26 weeks of supervised treadmill training. Blood samples for both groups were taken at baseline and after 26 weeks. view more
Credit: Florida Atlantic University
Increasing evidence shows that physical activity and exercise training may delay or prevent the onset of Alzheimer s disease (AD). In aging humans, aerobic exercise training increases gray and white matter volume, enhances blood flow, and improves memory function. The ability to measure the effects of exercise on systemic biomarkers associated with risk for AD and relating them to key metabolomic alterations may further prevention, monitoring, and treatment efforts. However, systemic biomarkers that can measure exercise effects on brain function and that link to relevant metabolic responses are lacking.
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Mayo researchers, collaborators identify ‘instigator’ gene associated with Alzheimer’s disease
JACKSONVILLE, Fla. – In a new paper published in Nature Communications, Mayo Clinic researchers and collaborators report the protein-coding gene SERPINA5 may worsen tau protein tangles, which are characteristic of Alzheimer’s disease, and advance disease. By combining clinical expertise, brain tissue samples, pathology expertise and artificial intelligence, the team clarified and validated the relevance of the gene to Alzheimer’s disease.
The researchers used tissue samples from 385 brains donated to the Mayo Clinic Brain Bank, which houses more than 9,000 brain tissue specimens for the study of neurodegenerative disorders. The samples were from people who were diagnosed with Alzheimer’s disease and lacked co-existing diseases found in the brain. This ensured a spotlight on Alzheimer’s disease, which enabled the team to focus on targets relevant to the disease.
Mayo researchers, collaborators identify instigator gene associated with Alzheimer s disease
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