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An international research team led by the University of British Columbia (UBC) has uncovered for the first time the importance of a small gland tucked behind the sternum that works to prevent miscarriage and diabetes in pregnant women.
The organ in question is the thymus, identified in a study published today in the journal
Nature as playing a significant role in both metabolic control and immunity in pregnancy.
How the immune system adapts to support mother and fetus has puzzled researchers for decades. The study conducted by an international research team, including UBC s Dr. Josef Penninger reveals an answer. The researchers have found that female sex hormones instruct important changes in the thymus, a central organ of the immune system, to produce specialized cells called Tregs to deal with physiological changes that arise in pregnancy.