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Stem cell transplants offer long-term benefits for pediatric cancer patients receiving immunotherapy Apr 1 2021 Children and young adults who receive CAR T-cell therapy for the most common childhood cancer - acute lymphoblastic leukemia - suffer remarkably fewer relapses and are far more likely to survive when the treatment is paired with a subsequent stem cell transplant, a new study finds. Daniel Trey Lee is conducting pioneering clinical research in the battle against childhood cancer. Image Credit: UVA Health The research, with an average follow up of nearly five years, suggests that stem cell transplants offer long-term benefits for young patients who receive the cutting-edge immunotherapy. CAR T-cell therapy results in complete remission in 60%-100% of patients initially, but the relapse rate is high. However, among those who received a stem cell transplant after CARs, the relapse rate was less than 10% two years later.

Cindy delbrookMaryalice stetler stevensonHaneen shalabiEvah bakerSethm steinbergEmily hendersonDavidf stroncekDaniel trey leeDanielw leePamelal woltersBonnie yatesStaci martinNiralin shahNational cancer instituteNational institutes of health intramural research programCancer center