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Tissue architecture impacts the evolutionary course of cancer

Tissue architecture impacts the evolutionary course of cancer Tumors are genetically diverse with different mutations arising at different times throughout growth and development. Many models have tried to explain how genetic heterogeneity arises and what impact these alterations have on tumor growth. In a new article published in Nature Communications, Moffitt Cancer Center researchers show how the location of the tumor and spatial constraints put on it by the surrounding tissue architecture ...
Sandy Anderson Emily Henderson Nature Communications Mathematical Oncology Department At Moffitt Researchers In Moffitt Center Moffitt Cancer Center

Moffitt researchers demonstrate tissue architecture regulates tumor evolution

Credit: Moffitt Cancer Center TAMPA, Fla. -- Tumors are genetically diverse with different mutations arising at different times throughout growth and development. Many models have tried to explain how genetic heterogeneity arises and what impact these alterations have on tumor growth. In a new article published in Nature Communications, Moffitt Cancer Center researchers show how the location of the tumor and spatial constraints put on it by the surrounding tissue architecture impact genetic he...
Sandy Anderson Nature Communications National Cancer Institute Moffitt Center Researchers In Moffitt Center Moffitt Cancer Center

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