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Human challenge models to advance vaccines against respiratory pathogens

Human challenge models to advance vaccines against respiratory pathogens World Immunisation Week 2021 To mark World Immunisation Week 2021 from 24 to 30 April, the London School of Hygiene & Tropical Medicine (LSHTM) Vaccine Centre is hosting a series of webinars. The theme this year is ‘Vaccines Bring Us Closer’. Each day of the week we focus on an important area of vaccine research, science and debate bringing together experts in the field. We end the week with the Vaccine Centre Annual Lecture on 30 April.  In this event, we focus on the use of controlled human infection models to accelerate the development of the next generation of vaccines against bacterial and viral respiratory pathogens, such as pertussis and SARS-CoV-2. Dr Chris Chiu will discuss The COVID-19 human challenge model and Professor Robert Read will explore Advancing the development of improved vaccines against pertussis through a human challenge model .

Underweight and overweight women at higher risk of successive miscarriages

Date Time Underweight and overweight women at higher risk of successive miscarriages A new study has shown that underweight and overweight women are at a significantly higher risk of experiencing recurrent miscarriages compared to those of average weight. A research team led by the University of Southampton assessed the link between women’s lifestyle and risk of recurrent pregnancy loss, defined as women having two or more consecutive early miscarriages. The systematic review and meta-analysis study has been published in the journal Scientific Reports. Miscarriage is the most common complication of early pregnancy, affecting 15 – 20% of all pregnancies. Recurrent pregnancy loss is a complex disease and although often attributed to numerous medical factors and lifestyle influences, the cause is deemed “unexplained” in around 50% of cases.

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