Microsoft 365 Defender is for the die-hard Microsoft enthusiast who knows how to work around its quirks. If you can fight through the confusing menus and have a high threshold for reading, there is a lot of power here, though you'll need to pay for it.
Bitdefender GravityZone Ultra is an even stronger offering than its Elite cousin. Combining its excellent protection and patch management with advanced EDR capabilities makes this one an easy sell for businesses with budget to spare.
F-Secure Elements suffers from some annoyances, but they're relatively minor when measured against its top-notch customization, threat detection, and endpoint detection and response (EDR) capabilities.