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MD Anderson Reveals Key Research Highlights for Jan 10, 2024

MD Anderson Research Highlights for January 10, 2024

The University of Texas MD Anderson Cancer Center’s Research Highlights showcases the latest breakthroughs in cancer care, research and prevention. These adva

MD Anderson Research Highlights for January 10, 2024

Mini Human Guts Shed Light on Cronkhite-Canada Syndrome

Research teams win Dunn Awards to fight cancer

Could Cancer's Microbiome Help Diagnose and Treat the Disease? | TS Digest

A growing appreciation of the bacterial assemblages that live within tumors has researchers striving to understand and capitalize on their role.

Protecting against Covid lung injury

An FDA-approved drug that has been in clinical use for more than 70 years may protect against lung injury and the risk of blood clots in severe

A Family's Experience Inspires a Career in Pancreatic Cancer Research

Mutant KRAS and p53 cooperate to drive pancreatic cancer metastasis

Date Time Mutant KRAS and p53 cooperate to drive pancreatic cancer metastasis Researchers at The University of Texas MD Anderson Cancer Center have discovered that mutant KRAS and p53, the most frequently mutated genes in pancreatic cancer, interact through the CREB1 protein to promote metastasis and tumor growth. Blocking CREB1 in preclinical models reversed these effects and reduced metastases, suggesting an important new therapeutic target for the deadly cancer. “To our knowledge, this is the first study to show how these two major genetic drivers work together to promote tumor growth and metastasis,” Kim said. “We learned that signaling downstream of mutant KRAS directly promotes mutant p53 activity. This discovery provides not only a new therapeutic target but unveils a vast transcriptional network that is activated downstream of these mutant proteins.”

Mutant KRAS and p53 cooperate to drive pancreatic cancer metastasis