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Nanotechnology Now - Press Release: University of Toronto researchers discover new lipid nanoparticle that shows muscle-specific mRNA delivery, reduces off-target effects: Study findings make significant contribution to generating tissue-specific ionizable lipids and prompts rethinking of mRNA vaccine design princi

Nanotechnology Now - Press Release: University of Toronto researchers discover new lipid nanoparticle that shows muscle-specific mRNA delivery, reduces off-target effects: Study findings make significant contribution to generating tissue-specific ionizable lipids and prompts rethinking of mRNA vaccine design princi
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United statesYue xuBowen liT leslie danKate richardsSteve southonJingan chenWave incUniversity of torontoInstitute of biomedical engineeringUniversity of toronto is canadaHome press university of torontoProceedings of the national academy sciencesLeslie dan facultyNational academyGairdner early career investigator

Researchers discover new lipid nanoparticle that shows muscle-specific mRNA delivery, reduces off-target effects

Researchers discover new lipid nanoparticle that shows muscle-specific mRNA delivery, reduces off-target effects
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United statesSteve southonJingan chenT leslie danYue xuBowen liInstitute of biomedical engineeringUniversity of torontoProceedings of the national academy sciencesLeslie dan facultyNational academyGairdner early career investigatorBiomedical engineering

University of Toronto researchers discover ne

<p>A team of researchers based at the <a href="https://www.pharmacy.utoronto.ca/">University of Toronto’s (U of T) Leslie Dan Faculty of Pharmacy</a> has discovered a novel ionizable lipid nanoparticle that enables muscle-focused mRNA delivery while minimizing off-target delivery to other tissues. The team also showed that mRNA delivered by the lipid nanoparticles investigated in their study triggered potent cellular-level immune responses as a proof-of-concept melanoma cancer vaccine.</p>

United statesKate richardsYue xuJingan chenBowen liT leslie danMethod of researchInstitute of biomedical engineeringUniversity of torontoProceedings of the national academy sciencesLeslie dan facultyNational academyGairdner early career investigatorBiomedical engineeringDan faculty