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Addition of Pembrolizumab to Chemotherapy Can Significantly Improve Survival Outcomes in Patients with Cervical Cancer

Expert discusses the long wait for an effective therapeutic option for persistent, recurrent, or metastatic cervical cancer and the potential widespread benefits of antibody drug conjugates like pembrolizumab.
United States University Of Arizona Bristol Myers Squibb Creighton University School Of Medicine University Of Arizona College Medicine National Comprehensive Cancer Network

Long-duration trastuzumab remains standard of care in HER2-positive breast cancer

CHICAGO — One-year of adjuvant trastuzumab remains the standard-of-care treatment duration for most patients with HER2-positive early breast cancer, according to study results presented at ASCO Annual Meeting.However, certain patients with low/intermediate HER2-positive early breast cancer may benefit from a shorter, 9-week course of trastuzumab (Herceptin, Genentech), researchers noted.
United States Devin Mclaughlin Byjennifer Southall Franco Conte Veneto Institute Of Oncology University Of Padua
Source: healio.com

Talazoparib extends PFS in maintenance regimen for small cell lung cancer subgroup

CHICAGO — Adding talazoparib to atezolizumab as maintenance treatment after front-line chemoimmunotherapy significantly lengthened PFS among adults with SLFN11-positive extensive-stage small cell lung cancer, according to a phase 2 study.Results of the randomized trial presented at ASCO Annual Meeting suggested that a biomarker-based approach to treating small cell lung cancer is feasible
United States Nagla Fawzy Abdel Karim Devin Mclaughlin Bydrew Amorosi Abdel Karim Inova Schar Cancer Institute
Source: healio.com

Patients report no quality-of-life issues with adjuvant regimen for high-risk liver cancer

CHICAGO — Individuals with high-risk hepatocellular carcinoma undergoing curative-intent procedures did not experience clinically meaningful deterioration in quality of life or function after adjuvant therapy, phase 3 study results showed.Patient-reported outcomes from the randomized IMbrave050 trial presented at ASCO Annual Meeting suggest that an adjuvant regimen of atezolizumab plus
United States Chugai Roche Masatoshi Kudo Mindy Valcarcel Timothy Kennedy Bydrew Amorosi
Source: healio.com

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Olaparib-durvalumab regimen prolongs PFS for certain women with advanced ovarian cancer

CHICAGO — First-line chemotherapy plus bevacizumab and durvalumab — followed by maintenance durvalumab, bevacizumab and olaparib — extended PFS compared with standard of care for women with non-BRCA-mutated advanced ovarian cancer.The findings of an interim analysis of the three-arm, randomized phase 3 DUO-O trial, presented at ASCO Annual Meeting, also noted a numerical
United States Devin Mclaughlin Carol Aghajanian Bymatthew Shinkle Genentech Roche Memorial Sloan Kettering Cancer Center
Source: healio.com

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