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B-cell system reset in CAR T-cell therapy 'feasible,' leads to durable remission in lupus

In patients with systemic lupus erythematous, CAR T-cell therapy appears to be a feasible and effective method of achieving durable remission, according to a speaker at the Biologic Therapies Summit.“Lupus patients often need quite substantial amounts of glucocorticoids to stay in remission, and that is a huge problem,” Georg Schett, MD, of Friedrich-Alexander University, in Germany,
Byerich Martin Shenaz Bagha Georg Schett Astellas Pharma Friedrich Alexander University Healio Rheumatology
Source: healio.com

Vaccine for pancreatic cancer shows promise in a small trial. Will this be the breakthrough everybody is looking for?

This trial is significant because pancreatic cancer is one of the most difficult solid tumour cancers to treat and the progress in treatments has been slow, says Dr Shailesh Shrikhande, who heads India's highest volume centre for pancreatic cancer surgery at Mumbai’s Tata Memorial Hospital
Shailesh Shrikhande Vinod Balachandran Tata Memorial Memorial Sloan Kettering Vaccine For Pancreatic Cancer Accine For Pancreatic Cancer News

MONALEESA-2 Subgroup Analysis Highlights Survival Benefit With Ribociclib/Letrozole in HR+ Breast Cancer

The frontline combination of ribociclib and letrozole significantly prolonged overall survival over letrozole alone in a subset of patients with hormone receptor–positive, HER2-negative advanced breast cancer who had de novo metastatic disease or late recurrence from neoadjuvant therapy, according to data from an exploratory analysis of the phase 3 MONALEESA-2 trial.
United States Baylor University Pierre Fabre Daiichi Sankyo Joyce Oshaughnessy Esmo Breast Cancer Annual Congress

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