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Adjuvant regimen has 'potential' to change practice in high-risk liver cancer

Adjuvant treatment with atezolizumab and bevacizumab extended RFS compared with active surveillance among patients with hepatocellular carcinoma, according to study findings presented at AACR Annual Meeting.The combination exhibited a generally manageable safety profile, results of the randomized phase 3 IMbrave050 trial showed.
United States Mindy Valcarcel Bymark Leiser Roche Ltd National Cancer Centre Singapore American Association For Cancer Research Annual Meeting
Source: healio.com

ReCode Therapeutics Appoints John G. Matthews, MBBS, MRCP, Ph.D., as Senior Vice President, Clinical

โ€“ Renowned physician-scientist brings deep expertise in clinical development and inhaled drug delivery to ReCode as lead programs for primary ciliary dyskinesia and cystic fibrosis enter clinical trials โ€“MENLO PARK, Calif.--(BUSINESS WIRE)--ReCode Therapeutics, a clinical-stage genetic medicines company using superi...
City Of United Kingdom Tara Cooper Johng Matthews Shehnaaz Suliman Sarah Mccabe

Perioperative durvalumab-based therapy reduces risk for adverse lung cancer outcomes

Patients with resectable non-small cell lung cancer who received perioperative durvalumab with neoadjuvant chemotherapy had significantly longer EFS and higher pathologic complete response rates than those who received chemotherapy alone.The combination also had a manageable safety profile consistent with previous studies, according to results of the randomized, double-blind phase 3 AEGEAN trial,
United States Johnv Heymach Bydevin Mclaughlin Mindy Valcarcel Spectrum Pharmaceuticals Eli Lilly Co
Source: healio.com

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Pre- and post-surgical immunotherapy-based treatment significantly improved lung cancer outcomes

A regimen of pre-surgical immunotherapy and chemotherapy followed by post-surgical immunotherapy significantly improved event-free survival (EFS) and pathologic complete response (pCR) rates compared to chemotherapy alone for patients with operable non-small cell lung cancer (NSCLC), according to Phase III trial results presented today by researchers from The University of Texas MD Anderson Cancer Center at the American Association for Cancer Research (AACR) Annual Meeting 2023.
United States Emily Henderson John Heymach American Association For Cancer Research Bristol Myers Squibb Jazz Pharmaceuticals

Pembrolizumab Yields High Response Rates for Patients With Unresectable Metastatic Desmoplastic Melanoma

Patients with unresectable metastatic desmoplastic melanoma achieved high response rates when treated with single-agent pembrolizumab in the SWOG S1512 trial, according to data presented during the 2023 AACR Annual Meeting.
United States Castle Biosciences Arthurg James Kari Kendra Iovance Biotherapeutics Department Of Oncologic Sciences

REGN5459 Delivers Dose-Dependent Responses in Relapsed/Refractory Myeloma

The BCMA- and CD3-directed bispecific antibody REGN5459 led to fast onset, deep, and dose-dependent responses sustained over time, with a high frequency of manageable low-grade cytokine release syndrome in patients with relapsed/refractory multiple myeloma.
Attaya Suvannasankha Regeneron Pharmaceuticals Inc Bristol Myers Squibb International Staging System Sutro Biopharma Inc Indiana University Simon Cancer Center

Perioperative Durvalumab Plus Neoadjuvant Chemo Improves pCR, EFS in Resectable NSCLC

Perioperative durvalumab plus neoadjuvant platinum-based chemotherapy demonstrated a statistically significant improvement in pathologic complete response and event-free survival vs placebo plus chemotherapy in patients with resectable nonโ€“small cell lung cancer.
United States Johnv Heymach Eli Lilly Co Bristol Myers Squibb Chugai Pharmaceuticals American Joint Committee On Cancer

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