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Genentech's Kadcyla Is the First Targeted Therapy to Show Significant Overall Survival Benefit in People With HER2-Positive Early-Stage Breast Cancer With Residual Invasive Disease After Neoadjuvant Treatment

– Phase III KATHERINE results reinforce Kadcyla as the standard of care for this population, with more than 82,000 people treated to date –– Long-term data also showed continued benefit in invasive disease-free survival for adjuvant Kadcyla compared to Herceptin in this study –– These data will be presented as an or...
South San Francisco United States San Antonio Bruno Eschli Levi Garraway Loren Kalm

Genentech's Inavolisib Combination Reduces the Risk of Disease Progression by 57% in People With Advanced Hormone Receptor-Positive, HER2-Negative Breast Cancer With a PIK3CA Mutation

– Inavolisib in combination with palbociclib and fulvestrant more than doubled progression-free survival compared to palbociclib and fulvestrant alone –– The inavolisib combination has the potential to address resistance to treatment and poor prognosis associated with PIK3CA mutations –– These new data are being pre...
San Antonio United States South San Francisco Bruno Eschli Levi Garraway Loren Kalm

EFS Benefit With Neoadjuvant Pembrolizumab/Chemo Combo, Adjuvant Pembrolizumab Upheld in High-Risk Early TNBC

Neoadjuvant pembrolizumab combined with chemotherapy followed by adjuvant pembrolizumab compared with placebo plus chemotherapy continued to show a clinically meaningful improvement in event-free survival in patients with high-risk, early-stage triple-negative breast cancer.
San Antonio United States Christabel Wilson Daiichi Sankyo Astellas Pharma Peter Schmid

Neoadjuvant Pembrolizumab Plus Chemo Improves pCR Across Key ER+ Breast Cancer Subgroups

The addition of pembrolizumab to neoadjuvant chemotherapy followed by adjuvant pembrolizumab plus endocrine therapy improved pathologic complete responses in key subsets of patients with early-stage, high-risk, estrogen receptor–positive/HER2-negative breast cancer enrolled in the phase 3 KEYNOTE-756 trial.
Baylor University United States San Antonio Samsung Bioepis Joyce Oshaughnessy Daiichi Sankyo

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IDEA trial: Skipping radiotherapy safe for younger postmenopausal patients with early-stage breast cancer

Almost all postmenopausal patients aged 50-69 years with stage I hormone receptor (HR)-positive breast cancer and low scores on a common genetic test who opted out of adjuvant radiotherapy were disease free five years after surgery, according to results from the IDEA clinical trial presented at the San Antonio Breast Cancer Symposium, held December 5-9, 2023.
San Antonio United States Lawrencew Davis Reshma Jagsi Emory University School Of Medicine Doris Duke Foundation

Neoadjuvant chemotherapy can eliminate need for regional nodal irradiation in breast cancer

For patients whose breast cancer converted from lymph node-positive to lymph node-negative disease after neoadjuvant chemotherapy, skipping adjuvant regional nodal irradiation (RNI) did not increase the risk of disease recurrence or death five years after surgery, according to results from the NRG Oncology/NSABP B-51/RTOG 1304 clinical trial presented at the San Antonio Breast Cancer Symposium, held December 5-9, 2023.
San Antonio United States Eleftherios Terry Mamounas Orlando Health Cancer Institute Biotheranostics Inc American Association For Cancer Research

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