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New method illuminates intricate interactions of the synaptonemal complex in nematodes

We have two copies of each chromosome in every cell in our bodies except in our reproductive cells. Sperm and egg cells contain a single copy of each chromosome with a unique mix of genes from our parents, an evolutionary trick to give our offspring genetic variability.
Lisa Kursel Aguayo Martinez Jesus Aguayo Martinez Ofer Rog Us National Institute Of Child Health Proceedings Of The National Academy Sciences

Study: High-fat diets impact genes in the intestines, brain, and immune system

A UC Riverside study to motivate your new year's resolutions: it demonstrates that high-fat diets affect genes linked not only to obesity, colon cancer and irritable bowels, but also to the immune system, brain function, and potentially COVID-19 risk.
United States Jose Martinez Lomeli Frances Sladek Poonamjot Deol University Of California Scientific Reports

Early-acting autophagy genes extend lifespan through alternative "garbage disposal" pathway in neurons

Autophagy, which declines with age, may hold more mysteries than researchers previously suspected. In the January 4th issue of Nature Aging, it was noted that scientists from the Buck Institute, Sanford Burnham Prebys and Rutgers University have uncovered possible novel functions for various autophagy genes, which may control different forms of disposal including misfolded proteins-;and ultimately affect aging.
United States La Jolla Caroline Kumsta Malene Hansen Sanford Burnham Prebys Monica Driscoll

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New AI tool spotlights hidden cancers for better diagnosis

A new artificial intelligence tool that interprets medical images with unprecedented clarity does so in a way that could allow time-strapped clinicians to dedicate their attention to critical aspects of disease diagnosis and image interpretation.
Daiwei David Zhang Mingyao Li Perelman School Of Medicine National Institutes Of Health University Of Pennsylvania School Medicine University Of Pennsylvania

"Genetic priority score" promises to revolutionize drug development

Driven by the need for a better way to prioritize targets for drug development, the Icahn School of Medicine at Mount Sinai has led the development of a novel "genetic priority score" (GPS) that will integrate various types of human genetic data into a single easy-to-interpret score.
United Kingdom North Yorkshire France General Iains Forrest Matthew Mort Avner Schlessinger

Hong Kong's first non-governmental patriotic education exhibition hall was opened

Hong Kong's first non-governmental patriotic exhibition hall opened in Hong Kong on January 1. The exhibition hall aims to provide a platform for understanding and learning Xi patriotic history. The event was organized by the Hong Kong Talent Service Association and Yingjie Museum, supported by China Mobile Hong Kong Co., Ltd. The organizers hope to establish mainstream values compatible with "one country, two systems" and strengthen the sense of identity of Hong Kong, Macao and Taiw...
Hong Kong Macau General Hong Kong Special Administrative Region Hong Kong General Dai Xiaolu Hong Kong Kevin Yeung

Small molecule-switchable RNA platform enables control of therapeutic protein expression

Just like a doctor adjusts the dose of a medication to the patient's needs, the expression of therapeutic genes, those modified in a person to treat or cure a disease via gene therapy, also needs to be maintained within a therapeutic window.
Yan Wang Jocelyn Duen Ya Jea Pei Wen Chao Department Of Pathology Doctoral Fellowship For Biomedical Research Baylor College Of Medicine

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