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Enterococci are a group of gram-negative bacteria that mostly inhabit the human gut. At present there are very few antibiotics that are capable of treating enterococcal infections but research is being done on developing many more.
The good news is that the U.S. FDA’s complete response letter (CRL) for Venatorx Pharmaceuticals Inc.’s intravenous antibiotic combination, cefepime-taniborbactam, in complicated urinary tract infections (cUTIs) requested no additional clinical testing. The bad news is the inevitable delay for a drug Venatorx and partner Melinta Therapeutics Inc. are aiming to position as a much-needed option for the fight against drug-resistant gram-negative infections.
2019 treatment guidelines published recommended ertapenem as a highly effective third-line therapy limited to a shorter course, as rescue therapy or during surgical planning.