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FDA Halts Fulcrum Trial, the Latest Setback in a Week of Sickle Cell Stumbles

Fulcrum Therapeutics offered few details about the clinical hold the FDA placed on its Phase 1b test of its sickle cell disease drug. Graphite Bio, Intellia Therapeutics, and Sangamo Therapeutics also encountered setbacks to their sickle cell programs.
United States United Kingdom Robert Gould Vertex Pharmaceuticals American Society Of Hematology Fulcrum Therapeutics

Science News Roundup: Graphite Bio pauses early-stage blood disease therapy trial; Former astronaut Cunningham, member of first crewed Apollo flight, dies at age 90 and more

A study published on Thursday explored the genetic dynamics of people in Norway, Sweden and Denmark dating back two millennia based on 297 genomes from ancient human remains and data from 16,638 modern Scandinavian men and women. Former astronaut Cunningham, member of first crewed Apollo flight, dies at age 90 Former U.S. astronaut Walter Cunningham, who flew to space aboard Apollo 7 in 1968 on the inaugural crewed Apollo mission that paved the way for the first human moon landing nine months ...
Walter Schirra Donn Eisele Walter Cunningham Graphite Bio Donn Eisele Walter Schirra

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Serious Side Effect Sidelines Gene-Edited Sickle Cell Therapy from Graphite Bio

Graphite Bio voluntarily paused a Phase 1/2 test of its gene-edited therapy for sickle cell disease after the first patient in the study developed a serious blood complication. The setback will also delay plans to reach the clinic with another genetic medicine in its pipeline.
Graphite Bio South San Francisco Based Graphite Bio Global Blood Therapeutics Weight Loss Medical Devices Healthcare Innovation

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