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Investigational protein replacement protects neonatal mice from deadly intestinal disease

Scientists from Stanley Manne Children's Research Institute at Ann & Robert H. Lurie Children's Hospital of Chicago and colleagues found that an investigational protein replacement – recombinant human insulin-like growth factor 1 and its binding protein-3 (rhIGF-1/BP3) – protected neonatal mice from necrotizing enterocolitis (NEC), a deadly intestinal disease that often strikes extremely premature infants.
United States Ann Roberth Lurie Manne Research Institute Pediatric Research Stanley Manne Children Research Institute

Boston College biologist wins NIH grant to study viral insulins for cancer treatment

Boston College Assistant Professor of Biology Emrah Altindis has been awarded a five-year, $2.5-million grant from the National Institutes of Health to study viral insulins and mechanisms related to IGF-1 receptor protein inhibition and its potential applications in cancer treatment.
Emrah Altindis National Institute Of Diabetes Altindis Lab Boston College National Institutes Of Health College Assistant Professor

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Study suggests CT imaging with automated AI system predicts EGFR genotype, identifying mutation status cost-effectively and non-invasively

Researchers developed an artificial intelligence (AI)-based predictive system (AIPS) model for the early detection of lung cancer by combining radiological, clinical, and genetic data.
Rajiv Gandhi Cancer Institute Lancet Regional Health Region Proposal Network Pyramid Network Lung Image Database Consortium Research Centre

Study shines light on partial endothelial-to-mesenchymal transition in the tumor microenvironment

Endothelial-mesenchymal transition (EndoMT, also termed as EndMT), a biological process resulting in the formation of mesenchymal (or lineage-committed) phenotypes from endothelial cells (lining blood vessels), plays a crucial role in tumor progression.
Kazuki Takahashi Miho Kobayashi Cancer Science Tokyo Medical Dental University Endothelial Cells

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