Tuning sterol extraction kinetics yields a renal-sparing polyene antifungal
Decades of previous efforts to develop renal-sparing polyene antifungals were misguided by the classic membrane permeabilization model1. Recently, the clinically vital but also highly renal-toxic small-molecule natural product amphotericin B was instead found to kill fungi primarily by forming extramembraneous sponge-like aggregates that extract ergosterol from lipid bilayers2–6. Here we show that rapid and selective extraction of fungal ergosterol can yield potent and renal-sparing polyen...
South Korea Fungal Priority Pathogens List To Guide Research Mcgraw Hill Laboratory Standards Institute Public Health Action World Organization Clinical Pharmacology
Source: nature.com