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Naturally occurring T cell mutations enhance engineered T cell therapies

Adoptive T cell therapies have produced exceptional responses in a subset of patients with cancer. However, therapeutic efficacy can be hindered by poor T cell persistence and function1. In human T cell cancers, evolution of the disease positively selects for mutations that improve fitness of T cells in challenging situations analogous to those faced by therapeutic T cells. Therefore, we reasoned that these mutations could be co-opted to improve T cell therapies. Here we systematically screened ...
Stadtmauer Edward Drug Discov Cell Biol
Source: nature.com

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At deadline for Massachusetts literacy bill, Governor Healey stays out of fray

Governor Healey on Monday said schools are ā€œfailingā€ students by not using up-to-date reading instruction, but she declined to say whether she supports legislation to require schools to choose instructional materials from a list of state-approved reading curriculums.
United States Patrick Tutwiler Kim Driscoll Mike Moriarty Nancy Duggan Jeffrey Riley

Jordan Strack: Sources indicate poor energy around Michigan, recommends firing Warde

Https://x.com/jordanstrack/status/1754895580474622331?s=46 Ā  ā€After talking with some people connected to Michigan & some in the coaching profession - things are not great right now in Ann Arbor. Jim Harbaugh held things together.Ā  President Ono is going to have to make the decision to move on from Warde Manuel & it has to happen soon.ā€
United States Ann Arbor Warde Manuel Michigan Athletics

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