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Supercomputing Helps Reveal Weaknesses in HIV-1 'Armor'

Supercomputing Helps Reveal Weaknesses in HIV-1 'Armor'
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Texas
United-states
Owen-pornillos
Gregory-voth
John-briggs
Juanr-perilla
Klaus-schulten
Haigp-papazian-distinguished-service-professor
Texas-advanced-computing-center
Max-planck-institute-of-biochemistry
University-of-delaware
Department-of-molecular-physiology

TACC: Frontera HPC Helps Reveal Weaknesses in HIV-1 'Armor'

10 Puzzling Mysteries Solved By Science

10 Puzzling Mysteries Solved By Science Despite centuries of study, the universe remains largely mysterious, as does the planet we call home. The unknown inspires both wonder and curiosity, which, in turn, often prompt questions. Seeking answers, we gather facts, form hypotheses, and conduct observations or experiments. Sometimes, we remain puzzled. The causes of unlikely phenomena, of seemingly impossible developments, and of strange occurrences continue to mystify us. At other times, however, we discover, we learn, and our knowledge expands. Nevertheless, new mysteries await. There are always more puzzles to solve. Each time we manage to unravel one of the mysteries of the universe, though, we are inspired again to seek more answers. We are a species with a need to know that can’t be satisfied, even when, through science, we manage to solve puzzling mysteries like the ten on this list.

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Cell 'bones' mystery solved with supercomputers

Loading video. VIDEO: Subunits B (blue), B-1 (cyan), and B-2 (gray) depicted as ribbon diagrams. Initially bound to B-1, subunit B unflattens, straining contact between subunits until they separate. The resulting loose lateral. view more  Credit: Vilmos Zsolnay, University of Chicago. Our cells are filled with bones, in a sense. Thin, flexible protein strands called actin filaments help support and move around the bulk of the cells of eukaryotes, which includes all plants and animals. Always on the go, actin filaments constantly grow, shrink, bind with other things, and branch off when cells move. Supercomputer simulations have helped solve the mystery of how actin filaments polymerize, or chain together. This fundamental research could be applied to treatments to stop cancer spread, develop self-healing materials, and more.

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Haigp-papazian-distinguished-service-professor
Yale-university
Texas-advanced-computing-center
Multidisciplinary-research-initiative-grant

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