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Scientists develop a rapid gene-editing screen to find effects of cancer mutations

MIT researchers found a way to screen cancer-linked gene mutations much more easily and quickly than existing approaches, using a variant of CRISPR genome-editing known as prime editing.

Tyler jacksFrancisco sanchez riveraDavid liuSamuel gouldDavidh kochKoch institute for integrative cancer researchSchool of science fellowship in cancer researchV foundation for cancer researchBroad instituteNational cancer institute center support grantKoch institute frontier awardHarvard university department of chemistryHoward hughes medical institute hanna gray fellowshipLudwig centerNational cancer instituteKoch institute

Rapid Gene-Editing Screen Developed to Detect Cancer Effects

Rapid Gene-Editing Screen Developed to Detect Cancer Effects
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United kingdomDavidh kochSamuel gouldFrancisco sanchez riveraTyler jacksDavid liuHarvard university department of chemistryBroad instituteKoch institute for integrative cancer researchKoch instituteIntegrative cancer researchThales papagiannakopoulosHarvard university departmentChemical biologyNature biotechnology

How the CCP Infiltrates the US Through Academia

How the CCP Infiltrates the US Through Academia
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CRISPR genome-editing technology helps scientists to explore many cancer-linked mutations

Genomic studies of cancer patients have revealed thousands of mutations linked to tumor development.

Stefani sprangerNimisha pattadaJennifer khirallahPeyton randolphGregory newbyKatie hollandChristina cabanaJessie davisGrissel cervantes jaramilloQiaobing xuKim mercerBrendan hortonAndrew anzaloneDavid liuSamuel gouldNicolas mathey andrews

CRISPR-Based Prime Editing Generates Mouse Models of Cancer Mutations

CRISPR-Based Prime Editing Generates Mouse Models of Cancer Mutations
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Nicolas mathey andrewsDavid liuDavidh kochZack elyTyler jacksKoch institute for integrative cancer researchBroad instituteJackson laboratoryHarvard university department of chemistryMassachusetts institute of technologyKoch instituteIntegrative cancer researchNature biotechnologyHarvard university departmentChemical biologyCancer genome atlas