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Objectives To assess the association between use of menopausal hormone therapy and development of dementia according to type of hormone treatment, duration of use, and age at usage. Design Nationwide, nested case-control study. Setting Denmark through national registries. Participants 5589 incident cases of dementia and 55 890 age matched controls were identified between 2000 and 2018 from a population of all Danish women aged 50-60 years in 2000 with no history of dementia or contraindications for use of menopausal hormone therapy. Main outcome measures Adjusted hazard ratios with 95% confidence intervals for all cause dementia defined by a first time diagnosis or first time use of dementia specific medication. Results Compared with people who had never used treatment, people who had received oestrogen-progestogen therapy had an increased rate of all cause dementia (hazard ratio 1.24 (95% confidence interval 1.17 to 1.33)). Increasing durations of use yielded higher hazard rati

National registry of patientsData protection regulation of european unionDanish data protection agencyWomen health initiative memory studyDanish society for pharmacoepidemiologyDanish cancer society scientific committeeDanish health data boardNovo nordiskNordic pharmacoepidemiological networkRr core teamInternational classification of diseasesNational prescription registryHealth initiative memory studyNational registryInternational classificationAnatomical therapeutic chemical