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Females' immune system edges out males but at a cost of higher autoimmune risk

A review article highlights how two X chromosomes in females influence immune system composition and function, leading to faster infection clearance and stronger vaccination responses but also a higher risk of autoimmune diseases.

Ustyna-shevchuk
Nature-reviews-immunology
Immune-system
Ntibody
Nti-inflammatory
Utoimmune-disease
Ell
Hromosome
Enes
Ormone
Mmunology

Historic DNA analysis identifies Down and Edwards syndromes in ancient humans

By analyzing ancient DNA, an international team of researchers have uncovered cases of chromosomal disorders, including what could be the first case of Edwards syndrome ever identified from prehistoric remains.

Greece
Finland
Bulgaria
Spain
Germany
Barcelona
Comunidad-autonoma-de-cataluna
Alicante
Valenciana
Spanish
Adam-ben-rohrlach
Jonathan-tuke

Xist lncRNA identified as key trigger in female-biased autoimmune diseases

Researchers uncover that the Xist ribonucleoprotein complex, unique to females, is a key driver of sex-biased autoimmunity, offering new insights into autoimmune disorders' higher prevalence in women.

Kateryna-kon-shutterstock
Stanford-university
Kateryna-kon
Autoimmune-disease
Utoimmunity
Ancer
Ardiovascular-disease
Ell
Hromosome
Ermatomyositis
Linefelter-syndrome
Upus

Ancient genomes reveal origins of multiple sclerosis risk in Europe

Researchers investigated the variables contributing to geographical heterogeneity in multiple sclerosis prevalence and the impact of genetic and environmental factors on the disease's development.

United-kingdom
British
Dorxela-shutterstock
Northern-europe
Bronze-ages
Medieval-age
United-kingdom-biobank
Pontic-steppe
Bronze-age
Multiple-sclerosis
Clerosis

New method illuminates intricate interactions of the synaptonemal complex in nematodes

We have two copies of each chromosome in every cell in our bodies except in our reproductive cells. Sperm and egg cells contain a single copy of each chromosome with a unique mix of genes from our parents, an evolutionary trick to give our offspring genetic variability.

Lisa-kursel
Aguayo-martinez
Jesus-aguayo-martinez
Ofer-rog
Us-national-institute-of-child-health
Proceedings-of-the-national-academy-sciences
University-of-utah
National-institute
Human-development
University-of-utah-biology-research-scholar-award
Rog-lab

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