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Study reveals immune dysregulation in Down syndrome and potential therapeutic strategy

People with Down syndrome, the condition caused by an extra copy of chromosome 21, or trisomy 21, display chronic dysregulation of their immune system, which can contribute to high rates of autoimmune conditions and severe complications from respiratory infections.

Megan craigAngela rachubinskiKeith smithJoaquin espinosaMatthew galbraithLinda crnic institute for down syndromeUniversity of colorado anschutz medical campusCrnic instituteNational institutes of healthGlobal down syndrome foundationData sciences programCrnic institute human trisomeTranslational sciences programScience advancesLinda crnic instituteDown syndrome

Scientists Unveil Harmful Impacts of Immune Hyperactivity in Down Syndrome, Offer Drug Repurposing Solution

Scientists Unveil Harmful Impacts of Immune Hyperactivity in Down Syndrome, Offer Drug Repurposing Solution
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United statesMatthew galbraithJoaquin espinosaAngela rachubinskiKeith smithUniversity of colorado anschutz medical campusNational institutes of healthUniversity of coloradoUchealth university of colorado hospitalTranslational sciences programData sciences programCrnic institute human trisomeLinda crnic institute for down syndromeCrnic instituteGlobal down syndrome foundationScience advances

Scientists uncover molecular mechanism contributing to defective heart development in Down syndrome

Infants born with Down syndrome, the genetic condition caused by an extra copy of chromosome 21, or trisomy 21, are highly predisposed to congenital heart defects.

United statesCongwu liJoaquin espinosaLily ramseyNational institutes of healthLinda crnic institute for downUniversity of colorado anschutz medical campusGlobal down syndrome foundationUniversity of coloradoColorado anschutz medical campusKunhua songHuman trisome projectLinda crnic instituteNational institutesGlobal down syndromeDown syndrome

Scientists Uncover Mechanism Affecting Heart Development in Down Syndrome

Scientists Uncover Mechanism Affecting Heart Development in Down Syndrome
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United statesJoaquin espinosaCongwu liLinda crnic institute for downGlobal down syndrome foundationUniversity of coloradoNational institutes of healthUchealth university of colorado hospitalUniversity of colorado anschutz medical campusColorado anschutz medical campusKunhua songHuman trisome projectLinda crnic instituteNational institutesGlobal down syndromeColorado anschutz medical

Scientists discover mechanism affecting heart development in Down syndrome

Scientists discover mechanism affecting heart development in Down syndrome
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United statesCongwu chiJoaquin espinosaUniversity of colorado anschutz medical campusUniversity of coloradoLinda crnic institute for downColorado anschutz medical campusKunhua songHuman trisome projectLinda crnic institute