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### What you need to know As of March 2023, when the Office for National Statistics stopped collecting data on this condition, 1.879 million individuals had self-assessed as having long covid symptoms lasting more than 12 weeks following acute covid-19 infection. Of these, the proportion of individuals with symptoms lasting two years or more is around 42%, suggesting a decline in new cases of long covid but a persistence of those with ongoing symptoms.1 Some systematic reviews and meta-analyses have reported that up to a third of such individuals have persistent symptoms of cognitive impairment,23 but estimates vary widely and are complicated by methodological heterogeneity eg, study size, assessment approach, follow-up duration, and different sampling frames (from self-reported surveys4 to large retrospective matched cohort studies of health records5), as discussed in a recent meta-analysis.6 The pathological underpinnings and potential therapeutic possibilities for cognitive impair

Ian tucker bellJuliel darbyshireZacc falopeEmma laddsNawar diar bakerlyTrisha greenhalghWellcome trust dphilOffice for national statisticsCare researchDepartment of healthNational institute for healthConsortium seeWellcome trustDiar bakerlyNational statisticsNational institute