Prevalent, protective, and convergent IgG recognition of SARS-CoV-2 non-RBD spike epitopes
Most analyses of the antibody responses induced by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection have focused on antibodies cloned from memory B cells. This approach has led researchers to conclude that neutralizing antibodies (nAbs) primarily target the receptor-binding domain (RBD) of the viruss spike protein. Voss et al. took a different approach, using proteomic deconvolution of the serum immunoglobulin G antibody repertoire from four COVID-19 convalescent patients. ...
United States San Francisco University Of California Lamontagne Center Ut System Proteomics Network National Institute Of Allergy
Source: sciencemag.org