Less is More for Next Generation of CAR T Cells
Date Time Less is More for Next Generation of CAR T Cells PHILADELPHIA—When researchers from Penn Medicine found that many patients with B-cell acute lymphoblastic leukemia (ALL) treated with the investigational chimeric antigen receptor (CAR) T cell therapy targeting the CD22 antigen didn’t respond, they went back to the drawing board to determine why. They discovered that less is more when it comes to the length of what is known as the single-chain variable fragment — the linker that br...
University Of Pennsylvania United States Nathan Singh Saari Gill Marco Ruella Emily Whitehead Foundation
Source: miragenews.com