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Researchers in England are deliberately exposing volunteers to the coronavirus that causes COVID-19. The goal is to speed up the development of new vaccines and treatments. But exposing people to a potentially fatal disease with no particularly effective therapy strikes some as unnecessary, if not unethical. Human challenge experiments differ from other studies of COVID-19 in a very important respect. The main difference is the control, says Christopher Chiu, an infectious disease researcher at Imperial College London and lead scientist for the challenge study. He says with a challenge study, you know exactly when a person was exposed to the virus, and exactly how much virus they were exposed to.

City ofUnited kingdomSeema shahChristopher chiuKanta subbaraoImperial college londonWorld health organization collaborating centre for referenceImperial college chiuNorthwestern university feinberg school of medicineRoyal free hospitalNorthwestern university feinberg schoolWorld health organization collaborating centreImperial collegeSouthern californiaLos angelesSouthern california public radio