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Over the past weeks, CMS has issued billing and coding guidance for newly authorized COVID-19 vaccines and treatments. This guidance information further implements policy and regulatory revisions made by CMS in the Interim Final Rule published in the Federal Register on November 6, 2020 (IFR), the agency s fourth COVID-19 rulemaking. Since the issuance of the IFR, CMS has provided instructions and toolkits via its website concerning billing for COVID-19 vaccines and monoclonal antibody COVID-19 infusion, and most recently, on December 18, 2020, for the new COVID-19 Treatments Add-On Payment payable to hospitals under the Medicare Inpatient Prospective Payment System (IPPS).