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This potential preventive treatment for Crohn’s disease was tested on a mouse model and on immune-reactive T cells from patients with Crohn’s disease. A potential preventive treatment for Crohn’s disease, a form of inflammatory bowel disease, has been demonstrated in a mouse model and using immune-reactive T cells from patients with Crohn’s disease.  This research, led by University of Alabama at Birmingham researcher Charles O. Elson, M.D., professor of medicine, focused on a subset of T cells known as T memory, or Tm cells. The UAB researchers used a triple-punch treatment to remove Tm cells and increase the number of T regulatory, or Treg, cells. Both of these results were able to prevent colitis in a T cell transfer mouse model, and they had similar inhibitory effects on immune-reactive CD4-positive T cells isolated from Crohn’s disease patient blood samples. 

Peterj mannonQing zhaoCharleso elsonBasili hirschowitzKatiel alexanderCraigl maynardFengyuan huangColitis foundationDepartment of pathologyNational institutes of healthInformatics instituteDepartment of geneticsDepartment of medicineUniversity of alabama at birminghamScience immunologyNational institutes