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 E-Mail IMAGE: Xiaoqin Zou, professor of physics, biochemistry, and a member of the Dalton Cardiovascular Research Center and Institute for Data Science and Informatics at the University of Missouri view more  Credit: University of Missouri Dozens of commonly used drugs, including antibiotics, antinausea and anticancer medications, have a potential side effect of lengthening the electrical event that triggers contraction, creating an irregular heartbeat, or cardiac arrhythmia called acquired Long QT syndrome. While safe in their current dosages, some of these drugs may have a more therapeutic benefit at higher doses, but are limited by the risk of arrhythmia. Through both computational and experimental validation, a multi-institutional team of researchers has identified a compound that prevents the lengthening of the heart s electrical event, or action potential, resulting in a major step toward safer use and expanded therapeutic efficacy of these medications when take

Jianmin cuiMira cohenXiaoqin zouInstitute for data scienceSkandalaris centerInstitute of clinicalEntrepreneurial acceleration programOffice of technology managementWashington university office of technology managementTranslational sciencesUniversity of missouriResearch innovation in biotechnologyProceedings of the national academy sciencesDalton cardiovascular research centerWashington university in stInstitute for molecular cardiology