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Salk researchers uncover molecular mechanisms of HIV drug resistance

Salk Institute researchers, in collaboration with the National Institutes of Health, have discovered the molecular mechanisms by which the human immunodeficiency virus (HIV) becomes resistant to Dolutegravir, one of the most effective, clinically used antiviral drugs for treating HIV.
Dmitry Lyumkis Indrani Choudhuri Allan Haldane Avik Biswas Stephenh Hughes Mamuka Kvaratskhelia

Revealing HIV drug-resistance mechanisms thro

Salk Institute researchers, in collaboration with the National Institutes of Health, have discovered the molecular mechanisms by which the human immunodeficiency virus (HIV) becomes resistant to Dolutegravir, one of the most effective, clinically used antiviral drugs for treating HIV. Their findings reveal how changes to the 3D structures of integrase, an HIV protein, can lead to Dolutegravir resistance and how other compounds may be able to overcome this resistance.
Lorenzo Briganti Zhaoyang Li Stephenh Hughes Qinfang Sun Zelin Shan Allan Haldane

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Two regions in the canine genome explain one third of the risk of rare blood cancer

 E-Mail Mutations in two genetic regions in dogs explain over one third of the risk of developing an aggressive form of hematological cancer, according to a study led by Jacquelyn Evans and Elaine Ostrander at the National Human Genome Research Institute in Maryland, USA and colleagues. The study, which combined multiple sequencing techniques to investigate histiocytic sarcoma in retriever dogs, publishes May 13 in the open-access journal PLOS Genetics. Histiocytic sarcoma is an aggressive ca...
United States Elaine Ostrander Jacquelyn Evans Flint Animal Cancer Center National Human Genome Research Institute European Commission

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