SRSF2 Mutations Lead to Lessened Frequency of Polycythemia in Preclinical MPN Models
The presence of mutated SRSF2 in knock-in mouse models of JAK2 V617F–driven myeloproliferative neoplasms reduced the rate of polycythemia and hampered hematopoietic progenitor functions.
Yue Yang University Of Virginia School Medicine Department Of Biochemistry Blood Cancer Molecular Genetics Virginia School
Source: onclive.com