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Could Treatment Resistance be an Effect of Antidepressants?

Previously taking antidepressants could make individuals less likely to respond to treatment for bipolar II depression

The Whistleblower and Penn: A Final Accounting of Study 352

Clinicians Report Medication Harms at Personal and Professional Peril

Clinicians Report Medication Harms at “Personal and Professional Peril” Clinicians were sued by the pharmaceutical industry, received verbal threats, and at least one lost his job after reporting adverse effects. 2022 A new study documents what happens after clinicians report “very serious adverse drug/device reactions (ADRs)” of medications experienced by their patients. To be defined as a “very serious ADR,” it had to be caused by “severe toxicity,” according to the researchers. They focused on drugs with large settlements and large numbers of documented harmed patients. This ensures that the reported events were true and accurate. The paper revealed that even after clinicians made these reports, there was a long delay before the pharmaceutical company responsible would admit the harms to regulators. Eventually, these reports cost the pharmaceutical industry tens of billions of dollars in fines and lawsuits. But before then, the clinician

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