A team of Boston-based doctors is using novel technology that peers inside individual cells and catalogs every component, enabling the researchers to identify the features associated with pain.
Migraine and related headaches are caused by activity in a part of the nervous system known as the trigeminal ganglion (TG). However, it remains unclear which genes and cell types of the TG are involved. Now, by analyzing mouse and human TG, researchers from Brigham and Women’s Hospital and Massachusetts General Hospital profiled, at single-cell resolution, the genes expressed in each TG cell type. Their atlas may lead to the development of more effective treatments.