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Four-part small-molecule cocktail can prevent cellular stress

Four-part small-molecule cocktail can prevent cellular stress Researchers at the National Institutes of Health (NIH) have devised a four-part small-molecule cocktail that can protect stem cells called induced pluripotent stem cells (iPSCs) from stress and maintain normal stem cell structure and function. The researchers suggest that the cocktail could enhance the potential therapeutic uses of stem cells, ranging from treating diseases and conditions -- such as diabetes, Parkinsons disease and s...
Joni Rutter Emily Henderson National Center National Institutes Of Health Stem Cell Translation Laboratory Translational Sciences

Scientists identify small-molecule cocktail to improve stem cell use in research and disease treatments

Chen et al., Nature Methods Researchers at the National Institutes of Health have devised a four-part small-molecule cocktail that can protect stem cells called induced pluripotent stem cells (iPSCs) from stress and maintain normal stem cell structure and function. The researchers suggest that the cocktail could enhance the potential therapeutic uses of stem cells, ranging from treating diseases and conditions — such as diabetes, Parkinson’s disease and spinal cord injury — to genome edit...
Joni Rutter National Center Us Department Of Health Human Services National Institutes Of Health Drug Administration
Source: nih.gov

Scientists find small molecule cocktail to improve stem cell use in research, medicine

 E-Mail Researchers at the National Institutes of Health (NIH) have devised a four-part small-molecule cocktail that can protect stem cells called induced pluripotent stem cells (iPSCs) from stress and maintain normal stem cell structure and function. The researchers suggest that the cocktail could enhance the potential therapeutic uses of stem cells, ranging from treating diseases and conditions -- such as diabetes, Parkinsons disease and spinal cord injury -- to genome editing. Human pluripo...
Joni Rutter National Center Us Department Of Health Human Services National Institutes Of Health Discovery Into Health

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NIH funds large Phase 3 clinical trial to test repurposed drugs for treating COVID-19 symptoms

NIH funds large Phase 3 clinical trial to test repurposed drugs for treating COVID-19 symptoms Using an ACTIV master protocol, the trial will focus on potential interventions for mild-to-moderate illness. The National Institutes of Health will fund a large, randomized, placebo controlled Phase 3 clinical trial to test several existing prescription and over-the-counter medications for people to self-administer to treat symptoms of COVID-19. Part of the Accelerating COVID 19 Therapeutic Intervent...
United States North Carolina Vanderbilt University Franciss Collins Joni Rutter Emily Henderson

Large clinical trial to study repurposed drugs to treat COVID-19 symptoms

Using an ACTIV master protocol, the trial will focus on potential interventions for mild-to-moderate illness. The National Institutes of Health will fund a large, randomized, placebo‑controlled Phase 3 clinical trial to test several existing prescription and over-the-counter medications for people to self-administer to treat symptoms of COVID-19. Part of the Accelerating COVID‑19 Therapeutic Interventions and Vaccines (ACTIV) public–private partnership, the ACTIV-6 trial aims to provide e...
United States North Carolina Vanderbilt University Franciss Collins Joni Rutter National Center
Source: nih.gov

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