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Price: Scientists atSt. JudeChildren’s Research Hospital are working with colleagues in China to develop better therapy for childhood acute lymphoblastic leukemia (ALL). Results from a large phase 3 noninferiority clinical trial definitively showed that vincristine and dexamethasone pulses can be eliminated in patients with low-risk disease. The findings were published today in The Lancet Oncology. Adding the chemotherapy vincristine plus a steroid (originally prednis...
Hong Kong Hua Jiang University Of Hong Kong Hong Kong General Hui Jiang Hui Zhang

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Risk-directed childhood leukemia treatment takes a step forward

Date Time Risk-directed childhood leukemia treatment takes a step forward Corresponding author Ching-Hon Pui, M.D., St. Jude Oncology Department chair, helped discover how genomic analysis can improve outcomes for children with acute lymphoblastic leukemia. Comprehensive genomic analyses have helped researchers identify more than 20 subtypes of acute lymphoblastic leukemia (ALL) based on the genetic mutations that drive the disease. Research led by St. Jude Children’s Research Hospital scie...
Deqing Pei Elaine Coustan Smith Zhaohui Gu Dario Campana William Evans Mary Relling

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