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Radiometals and Radiohalogens: Potential New Combination for Cancer Treatment

Kanazawa, Japan – An approach called radiotheranostics involves a combination of a different kind for the treatment of cancer – namely, the

Kanazawa University research: Tracing tumors: targeting and imaging cancer cells

Share this article KANAZAWA, Japan, April 27, 2021 /PRNewswire/ -- In a recent study published in the journal Molecules researchers at Kanazawa University describe the use of novel gallium-based radiotracers to visualize tumors in the body. Cancer cells highly express specific proteins on their surface which helps oncologists identify and target these cells. For example, platelet-derived growth factor receptor β (PDGFRβ) which is often found on breast and colon cancer cells has been used to design probes that can attach to it and facilitate imaging of these cells. All such tracers designed to date have shown low accumulation within tumor tissues making it hard to visualize the cancer accurately. However, a team led by Kazuma Ogawa at Kanazawa University has now used radiolabeled gallium (Ga) to create tracers which showed potential when tested in mice.

Kanazawa University research: Tracing tumors: targeting and imaging cancer cells

Kanazawa University research: Tracing tumors: targeting and imaging cancer cells

Tracing tumors: targeting and imaging cancer cells

Cancer cells highly express specific proteins on their surface which helps oncologists identify and target these cells. For example, platelet-derived...

Blending old and new to fight pancreatic cancer

Date Time Blending old and new to fight pancreatic cancer Kanazawa, Japan – Bertolt Brecht, the German playwright, famously said, “Mixing one’s wines may be a mistake, but old and new wisdom mix admirably.” Now, researchers at Kanazawa University have shown that a combination of innovative immunomodulation with traditional chemotherapy may prove efficacious in combatting metastatic cancer of the pancreas. Pancreatic cancer is a dreaded malignancy, the commonest variant being pancreatic ductular adenocarcinoma (PDAC). Most patients present in advanced stages, with only about a fifth amenable to curative surgery at diagnosis. Conventional chemotherapy involves the drug Gemcitabine (GEM) but, unfortunately, the outcome is often bleak.