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Blood-clotting protein linked with tumor pathogenesis of CNS B-cell lymphoma
In people with central nervous system (CNS) lymphoma, cancerous B cells a type of white blood cell accumulate to form tumors in the brain or spinal cord, often in close proximity to blood vessels. This disease is quite rare, but individuals who are affected have limited treatment options and often experience recurrence.
Previous research has linked the severity of CNS lymphoma to abnormal leaks in the blood-brain barrier, a protective system that allows some substances to pass from the bloodstream to the brain, while blocking others. However, the specific molecular details of this link have been murky.