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Plumbing the dark genome for new genes

Plumbing the ‘dark’ genome for new genes Updated: Updated: This can aid diagnosis, cure diseases Share Article AAA New revelaton: Mutations in the novel regions do have physiological consequences, says Sudhakaran Prabakaran.   | Photo Credit: Rasi Bhadramani This can aid diagnosis, cure diseases On June 26, 2000, former U.S. President, Bill Clinton, announced the completion of a draft sequence of the human genome, a historic landmark for genetic research. The Human Genome Project helped map our genes, strengthened the study of human diseases and aided new drug discovery. But even after two decades, the number of ‘known’ genes – encoding around 20,000 ‘known’ proteins - has remained constant. It is also a conundrum why only 1.5% of the entire human genome codes for proteins.

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