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Integrated DNA Technologies, Beckman Coulter Life Sciences Ink Distribution Deal

New agreement enables IDT to offer customers plug-and-play automation and intuitive next-generation sequencing (NGS) technology to optimize library preparation protocolsCORALVILLE, Iowa & INDIANAPOLIS--(BUSINESS WIRE)--#Automation--Leveraging the power of forward-thinking automation technologies to drive genomics re...
Ann Arbor United States North Carolina United Kingdom Research Triangle Park San Diego

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Multiform antimicrobial resistance from a metabolic mutation

A critical challenge for microbiology and medicine is how to cure infections by bacteria that survive antibiotic treatment by persistence or tolerance. Seeking mechanisms behind such high survival, we developed a forward-genetic method for efficient isolation of high-survival mutants in any culturable bacterial species. We found that perturbation of an essential biosynthetic pathway (arginine biosynthesis) in a mycobacterium generated three distinct forms of resistance to diverse antibiotics, ea...
City Of United Kingdom Beckman Coulter Roche Lightcycler Dnase Ambion Fortune Lab

Vitamin D deficiency exacerbates UV/endorphin and opioid addiction

The current opioid epidemic warrants a better understanding of genetic and environmental factors that contribute to opioid addiction. Here we report an increased prevalence of vitamin D (VitD) deficiency in patients diagnosed with opioid use disorder and an inverse and dose-dependent association of VitD levels with self-reported opioid use. We used multiple pharmacologic approaches and genetic mouse models and found that deficiencies in VitD signaling amplify exogenous opioid responses that are ...
United States Santa Clara Allen Brian Atlas National Health Sheldong Adelson Medical Research Foundation John Wayne Cancer Institute Sequencing Center

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