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The power of pairing adaptive deconvolution with Computational Clearing

Deconvolution is a computational method used to restore the image of the object that is corrupted by the point spread function (PSF) along with sources of noise. In this technical brief, learn how the deconvolution algorithm offered by Leica Microsystems allows you to overcome losses in image resolution and contrast in widefield (WF) fluorescence microscopy due to the wave nature of light and the diffraction of light by optical elements. Explore the methods of user-controlled or automated dec
Leica Microsystems Application Note Light Microscopy

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Can Light Microscopy be Used to Visualize Viruses?

Image Credit: Likoper/Shutterstock.com L’occhio Della Mosca ( The Fly’s Eye) by Giambattista Odierna in 1644 CE. In that sensational book, the Italian naturalist provided the first detailed account of organic tissue – enabled by studying organic matter under the lens of newly invented microscopes. Now, the latest optical microscope technology is capable of imaging viruses that live in organisms. Conventional Light Microscopes: Widefield and Confocal Conventional light microscopes – wid...
Frits Zernike Giambattista Odierna Likoper Shutterstock Gabriella Ficz Ben Pilkington Georges Nomarski

New type of placental structure discovered in animals

New type of placental structure discovered in animals The Cyclostomata is an ancient group of aquatic colonial suspension-feeders from the phylum Bryozoa. The fact that they have unique placentae has been discovered by researchers at St Petersburg University and the University of Vienna. The coenocytes, i.e. large multinucleate cell structures, originate via nuclear multiplication and cytoplasmic growth among the cells surrounding the early embryo. Interestingly, the coenocytes are commonly fou...
Sankt Peterburg Uliana Nekliudova Andrew Ostrovsky White Sea Emily Henderson St Petersburg University

Biodegradable Nanoprobes Improve Cancer Diagnosis

Biodegradable Nanoprobes Improve Cancer Diagnosis Written by AZoNanoMar 12 2021 New nanoprobes, which were recently developed by Imperial College London (ICL) and tested in zebrafish, could help identify cancer more precisely and may support the diagnosis and treatment in the days to come. Purple cancer cells are labeled using bioharmonophores (white label). Image Credit: Imperial College London. To clearly visualize tumors in the body for cancer diagnosis, physicians can utilize miniature opti...
City Of United Kingdom Periklis Pantazis Royal Society College London Imperial Imperial College London

Tumours illuminated brightly and precisely with new biodegradable nanoprobe

 E-Mail To highlight tumours in the body for cancer diagnosis, doctors can use tiny optical probes (nanoprobes) that light up when they attach to tumours. These nanoprobes allow doctors to detect the location, shape and size of cancers in the body. Most nanoprobes are fluorescent; they absorb light of a specific colour, like blue and then emit back light of a different colour, like green. However, as tissues of the human body can emit light as well, distinguishing the nanoprobe light from the ...
City Of United Kingdom Claire Teulon Shuai Jiang Martina Konantz Claudia Lengerke

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