Markets in hong kong, united kingdom, germany and france all closed for easter monday. If you want to take a look at crude oil. Down by 44 cents. Wti looking like its trading at 52. 74. If you take a look at the currency markets, the florida is down. Dollar yen at 108. 28. The yield for the tenyear sitting at 2. 205 . A lot of things on the economic agenda today to think about in addition to geopolitics and whether youre willing to get 10,000 to get bump on a department that flight. Today, the National Association of Home Builders puts us its survey. Tomorrow and then wednesday, weve got the feds, facebook followed by the survey on friday. Friday, existing home sales. As for earning, heres what turns out. Nine dow compovnent and 63 s p 500 Companies Reporting this week. Netflix out for the day. Goldman sachs, morgan stanley. Other big names, united health, j j, ibm, travelers, verizon and ge. Also President Trump set to fill a key post. Randy quarles is expected to be named the feds vi
Military strength. And some signs of a not so roaring economy. Retail prices are dropping. U. S. Futures now pointing to more or less a mixed open. Shares of eli lilly are tumbling more than 5 in the free market, failing to receive fda approval for a new Rheumatoid Arthritis drug. Stocks are looking to bounce back after the dow and the s p ended the holiday shortened week with the worst day in three weeks. And retail sales slowed down for a second straight month. We have geopolitical concerns and the Vice President is sending north korea a message during his visit to south korea. While issues like that remain the president and i have great confidence that china will properly deal with north korea. But as President Trump made clear just a few short days ago, if china is unable to deal with north korea the United States and our allies will. Got the dollar today at a five month low versus the yen. People going for safety. We mentioned gold getting near within about 2 bucks almost of 1300.
The CONSORT (CONsolidated Standards Of Reporting Trials) 2010 statement is the standard guideline for reporting completed randomised trials. The CONSORT Dose-finding Extension (DEFINE) extends the guidance (with 21 new items and 19 modified items) to early phase dose-finding trials with interim dose escalation or de-escalation strategies. Such trials generally focus on safety, tolerability, activity, and recommending dosing and scheduling regimens for further clinical development. These trials are often inadequately reported, hampering their informativeness and making evidence informed decisions difficult. The CONSORT-DEFINE guidance aims to develop an international, consensus driven guideline for reporting early phase dose-finding trials to promote transparency, completeness, reproducibility, and facilitate the interpretation of the results. The CONSORT-DEFINE guidance provides recommendations for essential items that should be reported in early phase dose-finding trials to promote gr
SPIRIT (Standard Protocol Items: Recommendations for Interventional Trials) 2013 provides guidance for clinical trial protocol writing. However, neither the original guidance nor its extensions adequately cover the features of early phase dose-finding trials. The SPIRIT Dose-finding Extension (DEFINE) statement is a new guideline that provides recommendations for essential items that should be provided in the protocols of these trials. It details extensions to the SPIRIT 2013 guidance, incorporating 17 new items and modifying 15 existing items. The purpose of this guideline is to promote transparency, completeness, reproducibility of methods, and interpretation of early phase dose-finding trial protocols. It is envisioned that the resulting improvements in the design and conduct of early phase clinical trials will ultimately reduce research inefficiencies and inconsistencies, driving transformational advances in clinical care.
Developing an intervention is a lengthy process pursued in