Conclusions
In the present study, CNPs were successfully prepared; they had a relatively small and uniform particle size, and stable physical and chemical properties. CNPs can increase the Cur solubility, and β-CD block the drugs in mesoporous silicon channels and graft cRGD as targeting groups recognized by academia. And combined with EPR effect, we can achieve better tumor targeting. Moreover, CNP carriers demonstrated a low hemolysis rate and ideal cell compatibility, and they did not cause any obvious irritative damage to the intact skin. CNPs played an anti-cancer role by inducing apoptosis of S phase and G2/M phase cells. In vitro and in vivo experiments also showed that CNPs had good tumor-targeting ability and anti-tumor activity. In conclusion, CNPs have an ideal biosafety and therapeutic effect for recurrent BC.