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 E-Mail IMAGE: The movement of bacterial RNA Polymerase s Clamp and β-lobe (the purple and orange part in the picture, respectively) facilitates the DNA melting during initiation of transcription. view more  Credit: The Hong Kong University of Science and Technology The emergence and spread of new forms of resistance remains a concern that urgently demand new antibiotics. Transcription is a vital process in bacterial cell, where genetic information in DNA is transcribed to RNA for the translation of proteins that perform cellular function. Hence, transcription serves as a promising target to develop new antibiotics because inhibition the transcription process should effectively kill the bacteria. Bacterial RNA Polymerase, the core enzyme for transcription, must load the DNA and separate the double-stranded DNA to single stranded DNA to read the genetic information to initiate transcription. This process is also called DNA melting and is facilitated by the opening and c

Department of chemistryKyoto universityKing abdullah university of scienceDepartment of chemicalBiological engineeringMarkov state modelMarkov state modelsKing abdullah universityதுறை ஆஃப் வேதியியல்கியோட்டோ பல்கலைக்கழகம்கிங் அப்துல்லா பல்கலைக்கழகம் ஆஃப் அறிவியல்துறை ஆஃப் இரசாயனஉயிரியல் பொறியியல்மார்க்கோவ் நிலை மாதிரிமார்க்கோவ் நிலை மாதிரிகள்கிங் அப்துல்லா பல்கலைக்கழகம்